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Gmeiner, William
One or more keywords matched the following items that are connected to
Gmeiner, William
Item Type
Name
Academic Article
Gemcitabine (2',2'-difluoro-2'-deoxycytidine), an antimetabolite that poisons topoisomerase I.
Academic Article
Genome-wide mRNA and microRNA profiling of the NCI 60 cell-line screen and comparison of FdUMP[10] with fluorouracil, floxuridine, and topoisomerase 1 poisons.
Academic Article
Structural basis for topoisomerase I inhibition by nucleoside analogs.
Academic Article
A novel polypyrimidine antitumor agent FdUMP[10] induces thymineless death with topoisomerase I-DNA complexes.
Academic Article
The stability of a model substrate for topoisomerase 1-mediated DNA religation depends on the presence of mismatched base pairs.
Academic Article
Unique dual targeting of thymidylate synthase and topoisomerase1 by FdUMP[10] results in high efficacy against AML and low toxicity.
Academic Article
Replication-dependent irreversible topoisomerase 1 poisoning is responsible for FdUMP[10] anti-leukemic activity.
Concept
DNA Topoisomerases, Type I
Academic Article
F10 cytotoxicity via topoisomerase I cleavage complex repair consistent with a unique mechanism for thymineless death.
Grant
DNA-DIRECTED EFFECTS OF FdUMP(N)
Grant
Development of a CF10 Predictive Gene Signature in CRC Organoids.
Search Criteria
DNA Topoisomerases Type I